Uses for Raloxifene

Raloxifene for Osteoporosis

Examples

(Evista)

Raloxifene is taken in pill form every day. It can be taken at any time during the day. It is used only for postmenopausal women.

How It Works

Raloxifene is a selective estrogen receptor modulator (SERM), which works like estrogen on bone. It also works like an "anti-estrogen" on breast tissue and the uterus. As a result, raloxifene:

• Prevents and treats osteoporosis by slowing bone thinning and causing some increase in bone thickness.
• Lowers the risk of breast cancer.

Why It Is Used

Raloxifene is used to prevent and treat osteoporosis in women.

Raloxifene can also be used to help prevent breast cancer in women who have a high risk for breast cancer.

How Well It Works

Bone. Studies show that raloxifene increases bone mineral density in the bones of the spine and neck. This lowers the risk for broken spinal bones. Although raloxifene works much like estrogen, it may not be as effective on bone.

Breast cancer. Among high-risk women, raloxifene lowers the risk of breast cancer about as much as tamoxifen does.

Side Effects

Side effects of raloxifene include:

• Hot flashes.
• Vaginal dryness.
• Leg cramps.
• Blood clots in deep veins (deep vein thrombosis). You may or may not have symptoms of deep vein thrombosis. Symptoms that occur in the legs include:
  • Swelling.
  • Warmth.
  • Pain or tenderness.
  • Redness.
  Sometimes life-threatening pulmonary embolism is the first sign that you have deep vein thrombosis. Pulmonary embolism is the sudden blockage of an artery in the lung. Blood clots in the deep veins of the leg are the most common cause of pulmonary embolism. Symptoms of pulmonary embolism include:
  • Sudden shortness of breath.
  • Chest pain that may get worse with a deep breath.
  • A cough that may bring up blood.
  • A fast heart rate.
• Uterine cancer (rare).

Less serious side effects include:

• Muscle and joint aches.
• Weight gain.
• Rash.

What To Think About

Raloxifene raises your risk of dangerous blood clots. So does bed rest. If you plan to have a surgery followed by bed rest, talk to your doctor about ways to reduce the risk of blood clots around the time of surgery.

Raloxifene should not be used in women who:

• Are pregnant or might become pregnant. If you are nursing, do not take raloxifene, because experts do not know if the drug passes through breast milk.
• Have a history of blood clots in their deep veins (venous thromboembolism, deep vein thrombosis, or pulmonary embolism).
• Are taking certain medicines, such as cholestyramine, to lower the amounts of cholesterol in the blood.
• Have liver disease.